C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17α-hydroxylase-C17,20-lyase: Synthesis and biological evaluationHAIDAR, Samer; HARTMANN, Rolf W.Archiv der Pharmazie (Weinheim). 2002, Vol 335, Num 11-12, pp 526-534, issn 0365-6233, 9 p.Article

17β-HSD2 inhibitors for the treatment of osteoporosis: Identification of a promising scaffoldWETZEL, Marie; MARCHAIS-OBERWINKLER, Sandrine; HARTMANN, Rolf W et al.Bioorganic & medicinal chemistry. 2011, Vol 19, Num 2, pp 807-815, issn 0968-0896, 9 p.Article

The adrenocortical tumor cell line NCI-H295R as an in vitro screening system for the evaluation of CYP11B2 (aldosterone synthase) and CYP11B1 (steroid-11β-hydroxylase) inhibitorsMÜLLER-VIEIRA, Ursula; ANGOTTI, Marc; HARTMANN, Rolf W et al.Journal of steroid biochemistry and molecular biology. 2005, Vol 96, Num 3-4, pp 259-270, issn 0960-0760, 12 p.Article

5-phenyl substituted 1-methyl-2-pyridones and 4'-substituted biphenyl-4-carboxylic acids. Synthesis and evaluation as inhibitors of steroid-5α-reductase type 1 and 2PICARD, Franck; SCHULZ, Tobias; HARTMANN, Rolf W et al.Bioorganic & medicinal chemistry. 2002, Vol 10, Num 2, pp 437-448, issn 0968-0896Article

Novel steroidal pyrimidyl inhibitors of P450 17 (17α-hydroxylase/C17-20-lyase)HAIDAR, Samer; EHMER, Peter B; HARTMANN, Rolf W et al.Archiv der Pharmazie (Weinheim). 2001, Vol 334, Num 12, pp 373-374, issn 0365-6233Article

6-Substituted 1H-quinolin-2-ones and 2-methoxy-quinolines: synthesis and evaluation as inhibitors of steroid 5α reductases types 1 and 2BASTON, Eckhard; PALUSCZAK, Anja; HARTMANN, Rolf W et al.European journal of medicinal chemistry. 2000, Vol 35, Num 10, pp 931-940, issn 0223-5234Article

Prediction of protein-protein interaction inhibitors by chemoinformatics and machine learning methodsNEUGEBAUER, Alexander; HARTMANN, Rolf W; KLEIN, Christian D et al.Journal of medicinal chemistry (Print). 2007, Vol 50, Num 19, pp 4665-4668, issn 0022-2623, 4 p.Article

Quantitative analysis of 5α-reductase inhibitors in DU145 cells using matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry and high-performance liquid chromatography/tandem mass spectrometryKANG, Min-Jung; MATHUR, Sonal; HARTMANN, Rolf W et al.Journal of mass spectrometry. 2004, Vol 39, Num 7, pp 762-769, issn 1076-5174, 8 p.Article

Discovery of inhibitors of MCF-7 tumor cell adhesion to endothelial cells and investigation on their mode of actionBILD, Thomas; JOSE, Joachim; HARTMANN, Rolf W et al.Archiv der Pharmazie (Weinheim). 2004, Vol 337, Num 12, pp 687-694, issn 0365-6233, 8 p.Article

Development of a simple and rapid assay for the evaluation of inhibitors of human 17α-hydroxylase-C_17,20-lyase (P450c17) by coexpression of P450c17 with NADPH-cytochrome-P450-reductase in Escherichia coliEHMER, Peter B; JOSE, Joachim; HARTMANN, Rolf W et al.Journal of steroid biochemistry and molecular biology. 2000, Vol 75, Num 1, pp 57-63, issn 0960-0760Article

Development and evaluation of a pharmacophore model for inhibitors of aldosterone synthase (CYP11B2)ULMSCHNEIDER, Sarah; NEGRI, Matthias; VOETS, Marieke et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 1, pp 25-30, issn 0960-894X, 6 p.Article

Synthesis and evaluation of 2'-substituted 4-(4'-carboxy- or 4'-carboxymethylbenzylidene)-n-acylpiperidines: Highly potent and in vivo active steroid 5α-reductase type 2 inhibitorsPICARD, Franck; BARASSIN, Stephan; MOKHTARIAN, Armand et al.Journal of medicinal chemistry (Print). 2002, Vol 45, Num 16, pp 3406-3417, issn 0022-2623Article

Stable expression of human 5α-reductase type II in COS1 cells due to chromosomal gene integration : a novel tool for inhibitor identificationREICHERT, Wolfgang; MICHEL, Armin; HARTMANN, Rolf W et al.Journal of steroid biochemistry and molecular biology. 2001, Vol 78, Num 3, pp 275-284, issn 0960-0760Article

Cyclohex-1-ene carboxylic acids: Synthesis and biological evaluation of novel inhibitors of human 5α reductaseBASTON, Eckhard; SALEM, Ola I. A; HARTMANN, Rolf W et al.Archiv der Pharmazie (Weinheim). 2003, Vol 336, Num 1, pp 31-38, issn 0365-6233, 8 p.Article

Synthesis and biological evaluation of 4-(4-(alkyl-and phenylaminocarbonyl)benzoyl)benzoic acid derivatives as non-steroidal inhibitors of steroid 5α-reductase isozymes 1 and 2SALEM, Ola I. A; SCHULZ, Tobias; HARTMANN, Rolf W et al.Archiv der Pharmazie (Weinheim). 2002, Vol 335, Num 2-3, pp 83-88, issn 0365-6233Article

Synthesis and evaluation of steroidal hydroxamic acids as inhibitors of p450 17 (17α-hydroxylase/C17-20-lyase)HAIDAR, Samer; KLEIN, Christian D. P; HARTMANN, Rolf W et al.Archiv der Pharmazie (Weinheim). 2001, Vol 334, Num 4, pp 138-140, issn 0365-6233Article

Design and synthesis of 1,3,5-trisubstituted 1,2,4-triazoles as CYP enzyme inhibitorsAL-SOUD, Yaseen A; HEYDEL, Michael; HARTMANN, Rolf W et al.Tetrahedron letters. 2011, Vol 52, Num 48, issn 0040-4039, 6307, 6372-6375 [5 p.]Article

Evaluation of 4'-substituted bicyclic pyridones as non-steroidal inhibitors of steroid 5α-reductaseMCCARTHY, Anna R; HARTMANN, Rolf W; ABELL, Andrew D et al.Bioorganic & medicinal chemistry letters (Print). 2007, Vol 17, Num 13, pp 3603-3607, issn 0960-894X, 5 p.Article

Protein-dynamics of the putative HCV receptor CD81 large extracellular loopNEUGEBAUER, Alexander; KLEIN, Christian D. P; HARTMANN, Rolf W et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 7, pp 1765-1769, issn 0960-894X, 5 p.Article

Discovery of selective CYP11B2 (aldosterone synthase) inhibitors for the therapy of congestive heart failure and myocardial fibrosisHARTMANN, Rolf W; MÜLLER, Ursula; EHMER, Peter B et al.European journal of medicinal chemistry. 2003, Vol 38, Num 4, pp 363-366, issn 0223-5234, 4 p.Conference Paper

Synthesis of 6-or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitorsLEZE, Marie-Pierre; PALUSCZAK, Anja; HARTMANN, Rolf W et al.Bioorganic & medicinal chemistry letters (Print). 2008, Vol 18, Num 16, pp 4713-4715, issn 0960-894X, 3 p.Article

Discovery of a new class of bicyclic substituted hydroxyphenylmethanones as 17β-hydroxysteroid dehydrogenase type 2 (17β-HSD2) inhibitors for the treatment of osteoporosisWETZEL, Marie; GARGANO, Emanuele M; HINSBERGER, Stefan et al.European journal of medicinal chemistry. 2012, Vol 47, pp 1-17, issn 0223-5234, 17 p.Article

Influence of DNA Template Choice on Transcription and Inhibition of Escherichia coli RNA PolymeraseHAUPENTHAL, Joerg; HÜSECKEN, Kristina; NEGRI, Matthias et al.Antimicrobial agents and chemotherapy. 2012, Vol 56, Num 8, pp 4536-4539, issn 0066-4804, 4 p.Article

Steroidal carbonitriles as potential aromatase inhibitorsYADAV, Mange Ram; SABALE, Prafulla M; GIRIDHAR, Rajani et al.Steroids. 2012, Vol 77, Num 8-9, pp 850-857, issn 0039-128X, 8 p.Article

Triazole ring-opening leads to the discovery of potent nonsteroidal 17β-hydroxysteroid dehydrogenase type 2 inhibitorsKUIYING XU; AL-SOUD, Yaseen A; WETZEL, Marie et al.European journal of medicinal chemistry. 2011, Vol 46, Num 12, pp 5978-5990, issn 0223-5234, 13 p.Article